| Cancer - |
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Faculty:
Andy Deutsch, Vijay Hegde
The DNA Damage & Repair laboratory's mission is to understand genomic instability and its impact on aging and cancer etiology. |
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| Diabetes - |
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Faculty:
Jianping Ye, Zhanguo Gao
website: http://labs.pbrc.edu/generegulation
The Antioxidant and Gene Regulation lab's mission is to understand the cellular and molecular mechanisms of insulin resistance with long-term goal of identification of novel therapeutic targets for type 2 diabetes. |
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Faculty:
Eric Ravussin, Leanne Redman
The Skeletal Muscle Metabolism laboratory is focused on the measurement of skeletal muscle metabolism and seeks to understand and characterize the role of metabolic proteins and mitochondrial dysfunction in metabolic diseases including obesity, diabetes, insulin resistance and some muscle defects that occur with aging (sarcopenia and oxidative stress). Central to this investigation is the rhomboid mitochondrial protease named PARL and the adiponectin/AdipoR axis. |
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Faculty:
William Cefalu, Zhong Wang
website: http://brc.pbrc.edu
The primary mission of the Diabetes and Nutrition laboratory is to study the cellular mechanisms contributing to the development of insulin resistance in humans. In addition, their goal is to evaluate the clinical effect and mechanism of action by which dietary factors modulate insulin resistance. |
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Faculty:
Irina Obrosova,
The Mechanisms of Diabetes Complications laboratory's mission is to understand the pathogenesis of diabetes complications, especially neuropathy. |
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Faculty:
Steven Smith, Yourka Tchoukalova,
website: http://labs.pbrc.edu/endocrinology
The Endocrinology laboratory's mission is to harness multiple experimental approaches to understand the physiological, cellular and molecular connections between diets, particularly those high in fat, and the development of insulin resistance, a precursor to type 2 diabetes. |
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Faculty:
Krisztian Stadler
There is no description at this time. Please check back later. |
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| Epidemiology & Prevention - |
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Faculty:
Gang Hu
There is no description at this time. Please check back later. |
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Faculty:
Stephanie Broyles
There is no description at this time. Please check back later. |
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Faculty:
David Harsha
The Health Behaviors & Chronic Disease laboratory is researching the implementation of efficacy studies in behavioral interventions for cardiovascular disease, overweight, and metabolic syndrome, and the study of effectiveness of proven behavioral strategies in real world populations |
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Faculty:
Afschin Gandjour
There is no description at this time. Please check back later. |
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Faculty:
Catherine Champagne, Donna Ryan, Betty Kennedy
Nutritional epidemiology includes all studies of the relations between diet and health in human populations. To this end, the goal of this laboratory is to provide nutrition education and/or counseling that improve diet and health. |
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Faculty:
Peter Katzmarzyk
website: http://labs.pbrc.edu/physical_activity_epidemiology/
The focus of the Physical Activity Epidemiology Laboratory is on the effects of physical activity, fitness, and obesity on morbidity and mortality, and their impact on population health. These issues are examined using epidemiological approaches and large-scale population studies. |
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| Genomics & Molecular Genetics - |
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Faculty:
Robert Koza
There is no description available at this time. Please check back later. |
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Faculty:
Aamir Zuberi
The Functional Genomics laboratory is identifying and characterizing important and unknown polymorphic genes that influence susceptibility to dietary obesity and adipogenesis. |
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Faculty:
Randall Mynatt, Jingying Zhang
The Agouti Research Lab uses an integrative approach to understand the actions of the agouti protein and diet in obesity and diabetes. |
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Faculty:
Claude Bouchard, Tuomo Rankinen,
website: http://labs.pbrc.edu/humangenomics/
This lab investigates the genetic and molecular basis
of the response to a physically active lifestyle
with an emphasis on cardiorespiratory endurance, cardiovascular disease, and type 2
diabetes risk factors, as well as genetic and
molecular background of obesity and
abdominal obesity and their co-morbidities. |
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Faculty:
Leslie Kozak, Rea Anunciado-Koza
The Molecular Genetics and Thermogenesis laboratory is understanding biological processes associated with the obesity problem. |
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Faculty:
Michael Salbaum
There is no description available at this time. Please check back later. |
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Faculty:
Brenda Richards (Smith)
This laboratory investigates the genetic
basis for variation in the preferential
consumption of dietary fat or carbohydrate,
as well as total energy intake. |
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| Neurobiology - |
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Faculty:
Richard Rogers, Gerlinda Hermann, Maria Barnes
The Autonomic Neuroscience Lab has been interested in the relationship between the brain and the digestive tract for more than 20 years. Lately,
they have concentrated on how specific
neural circuits in the brainstem integrate
visceral afferent, descending neural
command, hormone and cytokine signals to
control digestive processes. |
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Faculty:
Roy Martin,
The theme of the Neurobehavior laboratory is “Nutrient (macronutrient) sensing mechanisms are important in the control of feeding behaviors.” Our goal is to modulate nutrient sensing mechanisms to control food intake and obesity. |
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Faculty:
Hans-Rudolf Berthoud, Huiyuan Zheng
The Neurobiology & Nutrition I laboratory's mission is to understand Neural mechanisms of nutrient detection, control of appetite and regulation of energy balance. |
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Faculty:
Christopher Morrison
The Neurosignaling Laboratory focuses on
the cellular mechanisms underlying the
neural regulation of body weight
homeostasis, with particular interest in the
signaling molecules and neuronal circuits
involved in the brain’s “perception” of
nutritional state and subsequent regulation of
feeding behavior. |
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Faculty:
Maria Barnes
There is no description at this time. Please check back later. |
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| Neurodegeneration - |
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Faculty:
Jeffrey Keller
There is no description available at this time. Please check back later. |
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Faculty:
Weihong Pan,
website: http://labs.pbrc.edu/bloodbrainbarrier
The Blood Brain Barrier I Laboratory's primary objective is to identify mechanisms, regulation, and clinical applications of cytokine transport across the blood-brain and blood-spinal cord barrier (BBB). |
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Faculty:
Abba Kastin,
The Blood Brain Barrier II Laboratory's primary objective is to determine the role of the blood-brain barrier (BBB) in neuroendocrine control, particularly in feeding behavior and alcoholism. |
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Faculty:
Gregory Holmes
The Neurotrauma & Nutrition laboratory's mission is to understand the effects of spinal cord injury upon GI reflexes and metabolism. |
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| Nutrient Sensing & Signaling - |
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Faculty:
Vishwa Dixit
There is no description available at this time. Please check back later. |
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Faculty:
Thomas Gettys
The Adipocyte Signaling lab investigates central mechanisms regulating SNS outflow to adipose tissue, mechanisms of SNS-dependent remodeling of adipose tissue, and functional consequences of adipose tissue remodeling |
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Faculty:
Indu Kheterpal
There is no description available at this time. Please check back later. |
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| Obesity - |
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Faculty:
George Bray, Phillip Brantley, Catherine Champagne, Timothy Church, Frank Greenway, David Harsha, Betty Kennedy, Corby Martin, Robert Newton, Tuomo Rankinen, Jennifer Rood, Donna Ryan, Steven Smith, Donald Williamson
The Diet, Physical Activity, & Behavior Modification Trials unit focuses on the mechanisms, effects and effectiveness of intentional weight loss and weight management through behavior, diet and activity modification. |
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Faculty:
Phillip Brantley, Valerie Myers, Heli Roy
The Behavioral Medcine laboratory is understanding interactions between biological, behavioral and psychosocial factors that relate to health promotion, risk factor reduction, disease management and adaptation to medical conditions associated with the metabolic syndrome including diabetes and cardiovascular disease. |
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Faculty:
Donald Williamson, Tiffany Stewart
website: http://labs.pbrc.edu/healthpsychology
The Health Behavior Research Group conducts research on behavioral approaches for the prevention and treatment of obesity and related metabolic disorders. This research involves testing the efficacy of community-based, internet-based, and clinic-based interventions for changes in health behaviors. |
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Faculty:
Nikhil Dhurandhar
The Infection and Obesity laboratory's mission is to understand obesity of infectious origin. |
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Faculty:
Corby Martin
There is no description available at this time. Please check back later. |
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Faculty:
George Bray, William Cefalu, Frank Greenway, Alok Gupta, Jennifer Rood, Donna Ryan, Steven Smith, Timothy Church
The outpatient clinical trials program focuses on obesity in areas of pharmaceutical development, dietary herbal supplements, foods and, more recently, medical devices. |
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Faculty:
Paula Geiselman
The Women's Health, Eating Behavior, & Smoking Cessation Program studies the robust role of fat and other macronutrient intake and fat preferences in the control of appetite and body weight in pre- and post-menopausal women following smoking cessation. |
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| Physical Activity & Health - |
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Faculty:
Marc Hamilton
There is no description at this time. Please check back later. |
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Faculty:
Robert Newton
There is no description at this time. Please check back later. |
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Faculty:
Timothy Church
There is no description available at this time. Please check back later. |
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Faculty:
Gregory Sutton
There is no description at this time. Please check back later. |
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| Stem Cell & Developmental Biology - |
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Faculty:
Claudia Kappen
There is no description available at this time. Please check back later. |
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Faculty:
Kenneth Eilertsen
The Epigenetics & Nuclear Reprogramming laboratory investigates 1) the epigenetic basis of nutritional programming that may occur in utero and contribute to later in life diseases such as obesity, hypertension and type 2 diabetes; 2) methods that reprogram the epigenome in ways that restore developmental and differentiation potential; and 3) epigenetic basis of liposarcoma differentiation. |
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Faculty:
Barbara Kozak
The Regenerative Biology Laboratory seeks to understand how tissues and organs can be rebuilt after injury or damage. |
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Faculty:
Jeffrey Gimble
The Stem Cell Biology Laboratory will focus on the characterization and understanding of adipose tissue, adult stem cells and especially the formation and development of adult stem cells. |
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Faculty:
Elizabeth Floyd
There is no description available at this time. Please check back later. |
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