Tuomo Rankinen, Ph.D.

Associate Professor

Human Genomics
(225) 763-3168
(225) 763-2525
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Ph.D., University of Kuopio, Finland, 1996, Clinical Nutrition
M.Sc., University of Kuopio, Finland, 1991, Clinical Nutrition


Dr. Rankinen’s areas of interest are genetic and molecular basis of human variation in responsiveness to exercise training.


Koivukoski L, Fisher SA, Kanninen T, Lewis CM, Von Wowern F, Hunt S, Kardia SL, Levy D, Perola M, Rankinen T, Rao DC, Rice T, Thiel BA, Melander O. Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3. Hum Mol Genet. 2004 Aug 4 [Epub ahead of print]

Loos RJ, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study. J Nutr. 2004 Jul;134(7):1772-8

Rauramaa R, Halonen P, Vaisanen SB, Lakka TA, Schmidt-Trucksass A, Berg A, Penttila IM, Rankinen T, Bouchard C. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med. 2004 Jun 15;140(12):1007-14

Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Lakka HM, Ukkola O, Boule N, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Bouchard C. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes. 2004 Jun;53(6):1603-8

Stanforth PR, Jackson AS, Green JS, Gagnon J, Rankinen T, Despres JP, Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH. Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: the HERITAGE Family Study. Int J Obes Relat Metab Disord. 2004 Jul;28(7):925-32

Bai F, Rankinen T, Charbonneau C, Belsham DD, Rao DC, Bouchard C, Argyropoulos G. Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium. J Med Genet. 2004 May;41(5):350-3

Collaku A, Rankinen T, Rice T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. Am J Clin Nutr. 2004 May;79(5):881-6

Sklan EH, Lowenthal A, Korner M, Ritov Y, Landers DM, Rankinen T, Bouchard C, Leon AS, Rice T, Rao DC, Wilmore JH, Skinner JS, Soreq H. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5512-7. Epub 2004 Apr 01

Janssen I, Katzmarzyk PT, Ross R, Leon AS, Skinner JS, Rao DC, Wilmore JH, Rankinen T, Bouchard C. Fitness alters the associations of BMI and waist circumference with total and abdominal fat. Obes Res. 2004 Mar;12(3):525-37

Snyder EE, Walts B, Perusse L, Chagnon YC, Weisnagel SJ, Rankinen T, Bouchard C. The human obesity gene map: the 2003 update. Obes Res. 2004 Mar;12(3):369-439. Review.

Rankinen T, Tiwari H. Genome scans for human nutritional traits: what have we learned? Nutrition. 2004 Jan;20(1):9-13

Leon AS, Togashi K, Rankinen T, Despres JP, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study. Metabolism. 2004 Jan;53(1):108-16

Tanaka S, Togashi K, Rankinen T, Perusse L, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP, Bouchard C. Sex differences in the relationships of abdominal fat to cardiovascular disease risk among normal-weight white subjects. Int J Obes Relat Metab Disord. 2004 Feb;28(2):320-3

Rico-Sanz J, Rankinen T, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study. Physiol Genomics. 2004 Jan 15;16(2):256-60. Epub 2003 Nov 18

Shephard RJ, Rankinen T, Bouchard C. Test-retest errors and the apparent heterogeneity of training response. Eur J Appl Physiol. 2004 Mar;91(2-3):199-203. Epub 2003 Oct 17

Rankinen T, Church TS, Rice T, Markward N, Leon AS, Rao DC, Skinner JS, Blair SN and Bouchard C. Effect of endothelin 1 genotype on blood pressure is dependent on physical activity and fitness levels. Hypertension 2007;50:1120-1125. (PMID: 17938376)

Rankinen T, Church T, Rice T, Markward N, Blair SN, Bouchard C. A Major Haplotype Block at the Rho-Associated Kinase 2 Locus is Associated with a Lower Risk of Hypertension in a Recessive Manner: the HYPGENE Study. Hypertens Res 2008;31:1651-1657. (PMCID: PMC2596921)

Rankinen T, Rice T, Teran-Garcia M, Rao DC, Bouchard C. FTO genotype is associated with exercise-induced changes in body composition: the HERITAGE Family Study. Obesity 2010;18:322-326 (PMCID: PMC2838609)

Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NBJ, Nielsen S, Åkerström T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJC, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL, Bouchard C. Using a molecular classifier to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol 2010;108:1487-1496. (PMCID: PMC2886694)

Rankinen T, Argyropoulos G, Rice T, Rao DC, Bouchard C. CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study. Circ Cardiovasc Genet 2010;3:294-299. (PMCID: PMC3045864)

Sarzynski MA, Rankinen T, Sternfeld B, Grove ML, Fornage M, Jacobs DR, Sidney S, Bouchard C. Association of single nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: The CARDIA Fitness Study. Circ Cardiovasc Genet 2010;3:531-538

Keller P, Vollaard NBJ, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG Timmons JA. A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol 2011;110:46-59. (PMCID: PMC3253010)

Bouchard C, Sarzynski MA, Rice T, Kraus W, Church T, Sung YJ, Rao DC, Rankinen T. Genomic predictors of maximal O2 uptake response to standardized exercise training programs. J Appl Physiol 2011;110:1160-1170. (PMCID: PMC3098655)

Rankinen T, Bouchard C. Genomic predictors of exercise training response. Curr Cardiovasc Risk Report 2011;5:368-372

Rankinen T, Sung YJ, Sarzynski M, Rao DC, Bouchard C. The heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. J Appl Physiol 2012;44:809-817.

Rankinen T, Bouchard C. Gene-exercise interactions. Prog Mol Biol Transl Sci 2012;108:447-460

Rice TK, Sarzynski MA, Sung YJ, Argyropoulos G, Stütz AM, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study. Eur J Appl Physiol 2012;112:2969-2978

Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Häkkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA, Rankinen T. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One 2012;7(5): e37887 (PMCID:PMC3364277)

Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T. Integrative Pathway Analysis of a Genome-Wide Association Study of VO2max Response to Exercise Training. Journal of Applied Physiology 2013;115:1343-59

Pérusse L, Rankinen T, Hagberg JH, Loos RJF, Roth SM, Sarzynski MA, Wolfarth B, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2012. Med Sci Sports Exerc 2013;45:824-31

Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T. Integrative Pathway Analysis of a Genome-Wide Association Study of VO2max Response to Exercise Training. J Appl Physiol 2013;115:1343-59

Roberts LD, Boström P, O’Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee Y-K, Palma MJ, Calhoun S, Georgiadi A, Chen M-H, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. Beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab 2014;19:96-108 ^ top