Thomas Gettys, Ph.D.

PI, Pennington Center of Biomedical Research Excellence
Professor

Department/Laboratory:
Nutrient Sensing and Adipocyte Signaling
Phone:
(225) 763-3165
 
Fax:
(225) 763-0274
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EDUCATION

Ph.D., Clemson University, Clemson, SC, 1984, Nutrition/Physiology

Postdoctoral Training, Vanderbilt University School of Medicine & Howard Hughes Medical Institute, Nashville, TN, Molecular Physiology

RESEARCH INTERESTS

Dr. Gettys has a broad interest in the signaling systems which link cell surface receptors to transcriptional programs regulating the metabolic and endocrine functions of adipose tissue. An additional area of interest includes the nutrient sensing mechanisms linking modulation of specific subsets of genes by dietary macronutrients, including lipids and amino acids.

SELECTED PUBLICATIONS

Stone, K.P., Wanders, D., Orgeron, M., Cortez, C. and Gettys, T.W. 2014. Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes Jun 19. pii: DB_140464. PMID: 24947368

Ghosh, S., Wanders, D., Stone, K.P., Van, N.T., Cortez, C.C., and Gettys, T.W. 2014. A systems biology analysis of the unique and overlapping transcriptional responses to calorie restriction and dietary methionine restriction in rats. FASEB J. 28: 2577-2590. PMCID:4021438

Hasek, B.E., Boudreau, A., Shin, J., Feng, D., Laque, A.I., Listi, D., Stewart, L.K., Prufer-Stone, K., Pessin, J., and Gettys, T.W. 2013. Transcriptional remodeling of the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction. Diabetes 62: 3362-3372. PMCID: 3781441.

Anthony, T.G., Morrison, C.D., and Gettys, T.W. 2013. Remodeling of lipid metabolism by dietary restriction of essential amino acids Diabetes 62: 2635-2644. PMCID:3717867

Wanders, D., Ghosh, S., Stone, K.P., Van, N.T., and Gettys, T.W. 2014. Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors 40: 13-26. PMCID:3796060

Plaisance, E.P., Greenway, F.L., Boudreau, A., Hill, K.L., Johnson, W.D., Perrone, C.E., Orentreich, N., Cefalu, W.T., and Gettys, T.W. 2011. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. Journal of Clinical Endocrinology & Metabolism 96: E836-840.

Hasek, B.E., Stewart, L.K., Henagan, T.M., Boudreau, A., Lenard , N., Black, C., Shin, J., Huypens, P., Malloy, V., Plaisance E., Krajcik, R.A., Orentreich, N., and Gettys, T.W. 2010. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. American Journal of Physiology 299: R728-739.

Plaisance, E.P., Henagan, T.M., Echlin, H., Boudreau, A., Lenard N.R., Hasek, B.E., Orentreich, N., and Gettys, T.W. 2010. Role of the ß3-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. American Journal of Physiology 299: R740-750. ^ top