Thomas Gettys, Ph.D.John Henry Hernandez Endowed Professorship in Health Promotion
PI, Pennington Center of Biomedical Research Excellence
Nutrient Sensing and Adipocyte Signaling
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EDUCATIONPh.D., Clemson University, Clemson, SC, 1984, Nutrition/Physiology
Postdoctoral Training, Vanderbilt University School of Medicine & Howard Hughes Medical Institute, Nashville, TN, Molecular Physiology
RESEARCH INTERESTSDr. Gettys has a broad interest in the signaling systems which link cell surface receptors to transcriptional programs regulating the metabolic and endocrine functions of adipose tissue. An additional area of interest includes the nutrient sensing mechanisms linking modulation of specific subsets of genes by dietary macronutrients, including lipids and amino acids.
SELECTED PUBLICATIONSWanders, D., Stone, K.P., Forney, L.A., Cortez, C.C., Dille, K.N., Simon, J., Xu, M., Hotard, E.C., Nikonorova, I.A., Pettit, A.P., Anthony, T.G., and Gettys, T.W. 2016. Role of GCN2-independent signaling through a non-canonical PERK/NRF2 pathway in the physiological responses to dietary methionine restriction. Diabetes Mar 2. pii: db151324. [Epub ahead of print]
Stone, K.P., Wanders, D., Calderon, L.F., Spurgin, S.B., Scherer, P.E., and Gettys, T.W. 2015. Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice. Obesity (Silver Spring) 23: 1836-1844. PMCID: 4551572
Patil, Y.N., Dille, K.N., Burk, D.H., Cortez, C.C., and Gettys, T.W. 2015. Cellular and molecular remodeling of inguinal adipose tissue by dietary methionine restriction. Journal of Nutritional Biochemistry 26: 1235-1247. PMCID: 4631695.
Wanders, D., Stone, K.P., Dille, K.N., Simon, J., Pierse, A., and Gettys, T.W. 2015. Metabolic responses to dietary leucine retriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling. Biofactors 41: 391-402. PMCID: 4715699.
Wanders, D., Burk, D.H., Cortez, C.C., Van, N.T., Stone, K.P., Baker, M., Mendoza, T., Mynatt, R.L., and Gettys, T.W. 2015. UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity. FASEB J. 29: 0000-0000. Epub ahead of print. PMID: 25742717
Stone, K.P., Wanders, D., Orgeron, M., Cortez, C. and Gettys, T.W. 2014. Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes 63: 3721-3733. PMCID: 4207389
Ghosh, S., Wanders, D., Stone, K.P., Van, N.T., Cortez, C.C., and Gettys, T.W. 2014. A systems biology analysis of the unique and overlapping transcriptional responses to calorie restriction and dietary methionine restriction in rats. FASEB J. 28: 2577-2590. PMCID:4021438
Hasek, B.E., Boudreau, A., Shin, J., Feng, D., Laque, A.I., Listi, D., Stewart, L.K., Prufer-Stone, K., Pessin, J., and Gettys, T.W. 2013. Transcriptional remodeling of the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction. Diabetes 62: 3362-3372. PMCID: 3781441.
Anthony, T.G., Morrison, C.D., and Gettys, T.W. 2013. Remodeling of lipid metabolism by dietary restriction of essential amino acids Diabetes 62: 2635-2644. PMCID:3717867
Wanders, D., Ghosh, S., Stone, K.P., Van, N.T., and Gettys, T.W. 2014. Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors 40: 13-26. PMCID:3796060
Plaisance, E.P., Greenway, F.L., Boudreau, A., Hill, K.L., Johnson, W.D., Perrone, C.E., Orentreich, N., Cefalu, W.T., and Gettys, T.W. 2011. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. Journal of Clinical Endocrinology & Metabolism 96: E836-840.
Hasek, B.E., Stewart, L.K., Henagan, T.M., Boudreau, A., Lenard , N., Black, C., Shin, J., Huypens, P., Malloy, V., Plaisance E., Krajcik, R.A., Orentreich, N., and Gettys, T.W. 2010. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. American Journal of Physiology 299: R728-739.
Plaisance, E.P., Henagan, T.M., Echlin, H., Boudreau, A., Lenard N.R., Hasek, B.E., Orentreich, N., and Gettys, T.W. 2010. Role of the ß3-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. American Journal of Physiology 299: R740-750. ^ top