Hans-Rudolf Berthoud, Ph.D.
George H. Bray Professorship
Neurobiology and Nutrition I - Berthoud
Ph.D., Swiss Federal Institute of Technology (ETH), Zürich, Switzerland, 1973
Dr. Berthoud is primarily interested in the role of the nervous system in the processes maintaining energy homeostasis and nutrient intake. This includes the receptors and pathways that allow the peripheral nervous system and the brain to sense the internal metabolic state and availability of important nutrients as well as the external food environment, the neural circuits integrating this information, and the behavioral, autonomic, and endocrine effector pathways leading to regulatory actions. Interests thus impinge on the areas of obesity and anorexia, gastrointestinal and liver physiology, gut-brain interactions, autonomic nervous system, cognitive neurosciences, taste physiology, and functional foods. The largely NIH funded research activities employ behavioral, neuroanatomical, neurochemical, and electrophysiological methods.
1) T. Babic, R.L. Townsend, L.M. Patterson, H. Zheng, and H.-R. Berthoud. Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway. Am J Physiol Regul Integr Comp Physiol 296(4):R845-54, 2009.
2) Shin, A.C., H. Zheng, and H.-R. Berthoud. An expanded view of energy homeostasis: neural integration of metabolic, cognitive and emotional drives to eat. Physiol Behav 97(5):572-80, 2009.
3) H. Zheng, N.R. Lenard, A.C. Shin and H.-R. Berthoud. Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond). 33 Suppl 2: S8-13, 2009.
4) Berthoud, H.-R. and C. Morrison. The brain, appetite, and obesity. Annu Rev Psychol 59:55-92, 2008.
5) Auberi, A.R., and H.-R. Berthoud. Neural systems controlling the drive to eat: mind versus metabolism. Physiology (Bethesda) 23:75-83, 2008.
6) Berthoud, H.-R. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil 20 (Suppl. 1):64-72, 2008.
7) Zuberi A.R., R.L. Townsend, L.M. Patterson, H. Zheng and H.-R. Berthoud. Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice. Eur J Pharmacol 585:14-23, 2008. PMCID: PMC2430069.
8) Wan S., K.N. Browning, G.M. Sutton, F.H. Coleman, A.A Butler, H.-R. Berthoud and R.A. Travagli. Presynaptic MC4-receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neuroscie 28:4957-4966. 2008.
9) Berthoud, H.-R. Paying the price for eating ice cream: is excessive GLP-1 signaling in the brain the culprit? Endocrinology 149: 4765-7, 2008.
10) Lenard, N.R. and H.-R. Berthoud. Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity (Silver Spring). 16 Supple 3: S11-22. 2008.
11) Wan, S., K.N. Browning, G.M. Sutton, F.H. Coleman, A.A Butler, H.-R. Berthoud and R.A. Travagli. Presynaptic MC4-receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neuroscie 28:4957-4966, 2008.