Director of Skeletal Muscle Metabolism
Assistant Professor, Director of Skeletal Muscle Physiology
John S McIlhenny Skeletal Muscle Physiology II
2002, Ph.D. (Molecular Biology/Physiology), Metabolic Research Unit. Deakin University/ ChemGenex Pharmaceuticals Limited, Australia.
1998, Honors in Applied Science (Health & Behavioral Sciences). Metabolic Research Unit. Deakin University, Australia.
1995, B.S. (Biological Science), Department of Biological and Chemical Science
My laboratory is focused on the measurement of skeletal muscle metabolism and investigates the molecular mechanism of mitochondrial dysfunction in metabolic diseases including obesity, diabetes, insulin resistance and some muscle defects that occur with aging (sarcopenia and oxidative stress). Central to this investigation is the rhombiod mitochondrial protease named PARL and the adipnectin/AdipoR axis.
Area of Interest:
Molecular Physiology; Mitochondrial bioenergetic
Molecular mechanisms of muscle insulin resistance and Aging
Metabolic and energy expenditure alterations in obesity and diabetes
Collier GR, McMillan JS, Windmill K, Walder K, Tenne-Brown J, de Silva A, Trevaskis J, Jones S, Morton GJ, Lee S, Augert G, Civitarese A, Zimmet PZ. Beacon: a novel gene involved in the regulation of energy balance. Diabetes. 2000 Nov;49(11):1766-71.
Walder K, McMillan JS, Lee S, Civitarese A, Zimmet P, Collier GR. Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats). Int J Obes Relat Metab Disord. 2001 Sep;25(9):1281-5.
Walder K, McMillan J, Lapsys N, Kriketos A, Trevaskis J, Civitarese A, Southon A, Zimmet P, Collier G. Calpain 3 gene expression in skeletal muscle is associated with body fat content and measures of insulin resistance. Int J Obes Relat Metab Disord. 2002 Apr;26(4):442-9.
Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia. 2004 May;47(5):816-20
K. Walder, L. Kerr-Bayles, A.E. Civitarese, J. Jowett , J. Curran, K. Elliott, J. Trevaskis, N. Bishara, P. Zimmet , L. Mandarino, E. Ravussin, J. Blangero, A. Kissebah, G. R. Collier. The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes., Diabetologia, 2005 Mar;48(3):459-68.
Leonie K. Heilbronn, Anthony E. Civitarese, Iwona Bogacka, Steven R. Smith, Matthew Hulver, Eric Ravussin. Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting. Obesity Research. 2005 Mar;13(3):574-81.
Anthony E. Civitarese, Matthijs K.C. Hesselink, Eric Ravussin, & Patrick Schrauwen. Glucose ingestion during exercise blunts exercise-induced expression of skeletal muscle fat oxidative genes. AJP; Endocrinology and Metabolism. 2005 Dec; 289(6):E1023-9.
Anthony E. Civitarese, Barbara Ukropcova, Stacy Carling, Matthew Hulver, Larry Mandarino, Ralph DeFronzo, Steven Smith & Eric Ravussin. Novel role for adiponectin pathway in human skeletal muscle mitochondrial bioenergetics. Cell Metabolism. 2006 Jul;4(1):75-87.
Anthony Civitarese, Matt Hulver, Stacy Carling, Steve Smith and Eric Ravussin. Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans. Submitted for Publication, Accepted for publication, PLoS Medicine. 2006.