Zhong Wang, M.D.

Assistant Professor Adjunct

Department/Laboratory:
Diabetes and Nutrition
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EDUCATION

M.D, Shanghai Medical University Shanghai, P.R. China, 1986, Endocrinology
Shanghai First Medical College, Shanghai, P.R. China, 1977, Medicine

RESEARCH INTERESTS

Dr. Wang is interested in several areas of research, including:

1. To study of the insulin resistant mechanism in obese and diabetic animal model and subjects.

2. To determine how calorie restriction regime affects insulin signal transduction pathway in the muscles of rodents and monkey. His laboratory has observed that calorie restriction significantly increased muscle IRS-1, IRS-2 protein abundance and PI 3 kinase activity in the monkey muscle.

3. To investigate the effect of alternative medicine (herbs such as Phytomedics, an alcoholic extract of Artemisia dracunculus) on insulin signal and glucose metabolism in cultured human skeletal muscle cells.

4. To analyze effect of micronutrition -trace element such as chromium, magnesium deficiency on insulin signal transduction pathway and AMPK pathway in primary cultured human skeletal muscle cells.

5. To measure sugar cane fiber supplementation prevents high fat diet induced obesity in C57BL/6J mice. Effect of dietary fiber on glucose and lipid metabolism in high-fat-diet fed mice (Pilot study of sugar cane fiber-functional food project).

6. To study the mechanism of human adenovirus 36 (Ad-36) results in obese and alters cellular signaling in cultured cells.

SELECTED PUBLICATIONS

Yu Y, Zhang XH, Ebersole B, Ribnicky D, Wang ZQ. Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice. Sci Rep. 2013 Nov 5;3:3142. doi: 10.1038/srep03142.

Wang ZQ, Zhang XH, Yu Y, Tipton RC, Raskin I, Ribnicky D, Johnson W, Cefalu WT. Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. Metabolism. 2013 May 20. pii: S0026-0495(13)00084-X. doi: 10.1016/j.metabol.2013.03.004. [Epub ahead of print]

Kirk-Ballard H, Wang ZQ, Acharya P, Zhang XH, Yu Y, et al. An Extract of Artemisia dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a Murine Model of Diabetes. PLoS ONE 8(2): e57112. doi:10.1371/journal.pone.0057112. (2013)

Wang ZQ, Yu Y, Zhang XH, Floyd E, Lian K, Cefalu WT. Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice. Nanomedicine 2012, 7:2999-3012.

Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, Cefalu WT. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem. 2011 Nov;22(11):1064-73. PMID: 21277185

Wang ZQ, Yu Y, Zhang XH, Qin JH, Floyd E. Gene expression profile in human skeletal muscle cells infected with human adenovirus type 36. Journal of Medical Virology. 2012, Aug;84(8):1254-66.

Stull AJ, Wang ZQ, Zhang XH, Yu Y, Johnson WD, Cefalu WT. Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African American. Diabetes. 2012 Apr 3

Scherp P, Putluri N, Leblanc GJ, Wang ZQ, Zhang XH, Yu Y, Ribnicky D, Cefalu WT, Kheterpal I. Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L. J Proteomics. 2012 Mar 26. [Epub ahead of print]

Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, Cefalu WT. Bioactives of
Artermisia dracunculus L. Mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells. Diabetes. 2012 Feb 7. [Epub ahead of print] PMID: 22315320

LeCapitaine NJ, Wang ZQ, Dufour JP, Potter BJ, Bagby GJ, Nelson S, Cefalu WT, Molina PE.
Disrupted anabolic and catabolic processes may contribute to alcohol-accentuated SAIDS-
associated wasting. J Infect Dis. 2011 Oct 15;204(8):1246-55.

Wang ZQ, Yu Y, Zhang XH, Floyd EZ and Cefalu WT. Human adenovirus 36 decreases fatty acid
oxidation and increases de novo lipogenesis in primary cultured human skeletal muscle cells by
promoting Cidec/FSP27 expression. Int J Obesity. 1–10, 2010 May 4. [Epub ahead of print]
PMID: 20440297

Wang ZQ, Cefalu WT. Current concept about chromium supplementation in type 2 diabetes and insulin resistance. 2010 Apr;10(2):145-51. PMID: 20425574

Wang ZQ, Floyd E, Qin J, Liu X, Yu Y, Zhang XH, Wagner JD, Cefalu WT. Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys. Diabetes. 58:1488-1498,2009. PMID: 19336678

Stewart LK, Wang Z, Ribnicky D, Soileau JL, Cefalu WT, Gettys TW. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia. 2009 Mar;52(3):514-23. PMID: 19142628

Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I. 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model.
Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E433-9. Epub 2009 Jan 6. PMID: 19126784

White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E291-9. Epub 2008 Nov 18. PMID: 19017730

Wang ZQ, Ribnicky D, Zhang XH, Raskin I, Yu Y, Cefalu WT. Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture. Metabolism. 2008 Jul;57(7 Suppl 1):S58-64. PMID: 18555856

Stewart LK, Soileau JL, Ribnicky D, Wang ZQ, Raskin I, Poulev A, Majewski M, Cefalu WT, Gettys TW. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism. 2008 Jul;57(7 Suppl 1):S39-46. PMID: 18555853

Floyd ZE, Wang ZQ, Kilroy G, Cefalu WT. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism. 2008 Jul;57(7 Suppl 1):S32-8. PMID: 18555852

Wang ZQ, Cefalu WT, Zhang XH, Yu Y, Qin J, Son L, Rogers PM, Mashtalir N, Bordelon JR, Ye J, Dhurandhar NV. Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling. Diabetes. 2008 Jul;57(7):1805-13. Epub 2008 Apr 16. PMID: 18420488

Cefalu WT, Ye J, Wang ZQ. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):78-81. Review. PMID: 18537692

Wang ZQ, Qin J, Martin J, Zhang XH, Sereda O, Anderson RA, Pinsonat P, Cefalu WT. Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation. Metabolism. 2007 Dec;56(12):1652-5. PMID: 17998017

Wang ZQ, Zuberi AR, Zhang XH, Macgowan J, Qin J, Ye X, Son L, Wu Q, Lian K, Cefalu WT. Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet. Metabolism. 2007 Dec;56(12):1635-42. PMID: 17998014

Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I. Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1503-10. Epub 2007 Sep 11. PMID: 17848630

Cefalu WT, Wang ZQ. Clinical research observations with use of exubera in patients with type 1 and 2 diabetes. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S28-40. No abstract available. PMID: 17563301

Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, Cefalu WT.Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 2006 Aug;29(8):1826-32. PMID: 16873787

Wang ZQ, Zhang XH, Russell JC, Hulver M, Cefalu WT. Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats. J Nutr. 2006 Feb;136(2):415-20. PMID: 16424121 ^ top