Sita Aggarwal, Ph.D

Assistant Professor-Research

Department/Laboratory:
William Hansel Cancer Prevention
Phone:
(225) 763-2931
 
Fax:
(225) 763-3022
Send E-mail 
 

EDUCATION

Degree-Granting Education
1999 Panjab University, Chandigarh, India, Ph.D, Life Sciences (Urolithiasis)
1993 Panjab University, Chandigarh, India, MS, Life Sciences (Biochemistry)
Postgraduate Training
Feb 2002-Feb 2007; MD Anderson Cancer Center, Houston, TX, USA
Jan 2000-Jan 2002; Institute of Microbial Technology, Chandigarh, India
June 1998- Sept 1999; Medical University of South Carolina, Charleston, SC, USA

RESEARCH INTERESTS

1) Destroying cancer cells, by developing new targeted drugs from natural defined plant extracts which destroy blood vessels in cancer cells, induces apoptosis in cancer cells; blocking energy utilization in cancer cells. I utilize nude mouse models, cancer cells, defined plant extracts and purified defined compounds from plants to understand the mechanism(s) underlying cancer cells proliferation.

2) The development of alternative drugs from natural resources such as plants for long term normalization of glycemic control in Type 2 Diabetes. I utilize mouse and human pancreatic beta cells, defined plant extracts to understand the mechanism(s) that influence beta cell mass, function and apoptosis.

SELECTED PUBLICATIONS

S. Ali, N. Karki, C. Bhattacharya, R. Zhu, D. A. MacDuff, M. D. Stenglein, A. J. Schumacher, Z. L. Demorest, R. S. Harris, A. Matin* and S. Aggarwal*. APOBEC3 inhibits DEAD-END function to regulate microRNA activity. BMC Molecular Biology; 14:16; 2013.

P. Magut ,S.Das, V. Fernand, J.Losso, , K. McDonough, B. Naylor, S. Aggarwal, I. Warner. Tunable Cytotoxicity of Rhodamine 6G via Anion Variations. Journal of the American Chemical Society; 135 (42), 15873-15879; 2013.

R. Krishnapuram , H. Kirk-Ballard, E. J. Dhurandhar, O. Dubuisson, V. Messier, Rémi R.-Lhoret, V.Hegde, S.Aggarwal, and N.V. Dhurandhar. Insulin Receptor-independent Up-regulation of Cellular Glucose Uptake. Int J Obes (Lond) 37(1):146-53; 2013.

M. Li, G.M. Ganea, C. Lu, S. L. De Rooy, B. El-Zahab, R. Jin, S. Aggarwal, and I. M. Warner. Lipophilic Phosphonium-Lanthanide Compounds with Magnetic, Luminescent, and Tumor Targeting Properties. J Inorg Biochem; 107(1):40-6; 2012. PMID: 22172501

S. Aggarwal*, M. W. Ndinguri, R. Solipuram, Nobuko Wakamatsu, R.P.Hammer , D.Ingram and W. Hansel*.[DLys6]-LHRH-Curcumin Conjugate Inhibits Pancreatic Cancer Cell Growth in vitro and in vivo. Int J Cancer; 129(7):1611-23; 2011. PMID: 21484797

A.M. Qaz , S. Aggarwal , C.S.Steffer, D.L. Bouwman , D.W.Weaver , S.A.Gruber , R.B.Batchu. Laser capture microdissection of pancreatic ductal adeno-carcinoma cells to analyze EzH2 by Western Blot analysis. Methods Mol Biol; 755:245-56; 2011. PMID: 21761309

M W. Ndinguri, R.Solipuram, R P. Gambrell, S. Aggarwal *, and R P. Hammer*. Peptide targeting of platinum anti-cancer drug. Bioconjugate Chem; 20 (10): 1869– 1878; 2009. PMCID: PMC2891414

S. Aggarwal, S.W. Kim, S.H. Ryu, W.C. Chug,F.H., and J.S .Koo. Growth Suppression of Lung Cancer Cells by Targeting Cyclic AMP Response Element-Binding Protein. Cancer Res; 68(4):981-988; 2008. PMCID: PMC2921320

C. Bhattacharya, S. Aggarwal, M. Kumar, M. Zhao, A.Ali, and A. Matin. Mouse Apolipoprotein B editing Complex 3 (APOBEC3) is expressed in Germ Cells and Interacts with Dead-end (DND1). PLos One; 3(5): e2315; 2008. PMCID: PMC2384002

C. Bhattacharya, S. Aggarwal, R. Zhu, M. Kumar, M. Zhao, M L. Meistrich, and A. Matin. The Mouse dead-end gene isoform alpha is Necessary for Germ Cell and Embryonic Viability. Biochem Biophy Res Commun; 355(1):194-9; 2007. PMCID: PMC1855146

S. Aggarwal, S.W. Kim, K. Cheon, F.H. Tabassam, J.H. Yoon and J.S .Koo. Nonclassical Action of Retinoic Acid on the Activation of the cAMP Response element-Binding Protein in Normal Human Bronchial Epithelial Cells. Mol Biol Cell; 17(2): 566-75; 2006. PMCID: PMC1356569

S. Aggarwal, H. Ichikawa, Y. Takada, S.K. Sandur, S. Shishodia and B. Aggarwal. Curcumin (Diferulolmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IkBalpha Kinase and Akt Activation. Mol Pharmacol; 69:195-206; 2006. PMID: 16219905

S. Aggarwal, Y. Takada, S. Chada, K. Sieger, A.M. Mhashilkar and B. Aggarwal. TNF Stimulates Transcription Factor NF-KB In The Presence Of Novel Melanoma Differentiation-associated Gene (mda7) Leads Cells Resistant towards Cell Killing. J. Immunol; 173(7): 4368-76; 2004. PMID: 15383566

S. Aggarwal, Y. Takada, S. Singh, J. Myers and B. Aggarwal Inhibition of Growth And Survival of Human Head And Neck Squamous Cell Carcinoma Cells by Curcumin Via Modulation of Nuclear Factor-kB Signaling. Int. J. Cancer; 111: 679-692; 2004. PMID: 15252836

Mehdi F. Moghadam, C. Tandon, S. Aggarwal, S. K. Singla, S.K. Singh, S.K. Sharma, G.C. Varshney and R.K. Jethi. Concentration Of a Potent Calcium Oxalate Monohydrate Crystal Growth Inhibitor In The Urine Of Normal Persons And Kidney Stone Patients By ELISA-based Assay System Employing Monoclonal Antibodies. J. Cell. Biochem; 90 (6): 1261-75; 2003. PMID: 14635198

J. Sarin, S. Aggarwal, R. Chaba, G. Varshney and Pradip K. Chakraborti. B Subunit of Phosphate Specific Transporter From Mycobacterium Tuberculosis Is a Thermostable ATPase J. Biol. Chem: 276 (48): 44590-44597; 2001. PMID: 11567022

S. Aggarwal, C.D. Tondon, M. Forouzandeh, S.K. Singla, R. Kiran and R.K. Jethi. Role of Biomolecules from Human Renal Stone Matrix on COM Crystal Growth. Mol. Cell. Biochem; 210: 109-119; 2000. PMID: 10976764

C.D. Tandon, M. Forounzandeh, S. Aggarwal and R.K. Jethi. Inhibitors of In Vitro Mineralization from Flexor Tendons of Rabbits and their Role in Biological Mineralization. Mol. Cell. Biochem; 171: 29-35; 1997. PMID: 9201692

C.D. Tandon, S. Aggarwal, M. Forouzandeh and R.K. Jethi. Inhibitors of In Vitro Mineralization from Rabbit Aorta and Their Role In Biomineralization. J. Cell. Biochem; 68: 1-12; 1997. PMID: 9518256

R. Kiran, R. Gera and S. Aggarwal. Biochemical Studies on Aldicarb Toxicity in Female Rats. Ecol. Env. & Cons; 165-7; 1996.

S. Aggarwal, A. Poonian and R. Kiran. Effect of Carbofuran Toxicity on Erythrocytes of Rats Kept on Low Protein diet. Poll Res; 15(3): 237-239; 1996. ^ top