Ji Suk Chang, Ph.D.
Nutrient Sensing and Adipocyte Signaling
Ph.D. Case Western Reserve University, OH, 2005, Molecular Biology
M.S. Case Western Reserve University, OH, 1999, Biochemistry
Dr. Chang has an interest in studying how external cues (e.g. diet, temperature, and exercise) regulate gene expression in a tissue-specific manner and how this regulatory network is altered in obesity and diabetes. Her research is currently focusing on the role of NT-PGC-1a, a short isoform of PGC-1a transcriptional coactivator, in the regulation of brown fat transcription programs in response to environmental and nutritional stimuli.
Jun HJ, Joshi Y, Patil U, Noland RC, Chang JS. (2014). NT-PGC-1a activation attenuates high-fat diet-induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism. Submitted to Diabetes.
Chang JS, Gettys TW. (2013). Analyzing phosphorylation-dependent regulation of subcellular localization and transcriptional activity of transcriptional coactivator NT-PGC-1alpha. Methods Mol Biol, 952:163-173.
Jun HJ, Gettys TW, Chang JS. (2012). Transcriptional activity of PGC-1a and NT-PGC-1a is differentially regulated by Twist-1 in brown fat metabolism. PPAR Res, 2012:320454.
Chang JS, Fernand V, Zhang Y, Shin J, Jun HJ, Joshi Y, Gettys TW. (2012). NT-PGC-1a is sufficient to link ß3-adrenergic receptor activation to the transcriptional and physiological components of adaptive thermogenesis. J Biol Chem, 287(12):9100-9111.
Chang JS, Huypens P, Zhang Y, Black C, Kralli A, Gettys TW. (2010). Regulation of NT-PGC-1a subcellular localization and function of PKA-dependent modulation of nuclear export by CRM1. J Biol Chem, 285(23), 18039-18050.
Zhang Y, Huypens P, Adamson AW, Chang JS, Henagan TM, Boudreau A, Lenard NR, Burk D, Klein J, Perwitz N, Shin J, Fasshauer M, Kralli A, Gettys TW. (2009). Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1 alpha. J Biol Chem, 284(47), 32813-32826.