Marc Hamilton, Ph.D.


Inactivity Physiology
(225) 763-3188
(225) 763-0905
Send E-mail 


University of Texas-Austin, BA 1987, Zoology
University of Texas-Austin, MA 1989, Exercise Physiology
University of South Carolina-Columbia, Ph.D. 1994, Exercise Physiology
University of Texas School of Medicine--Houston Fellow, 1997, Molecular Biology


Dr. Hamilton’s laboratory introduced the inactivity physiology paradigm, leading to the now rapidly emerging perspective that prolonged sedentary time (predominantly sitting) is a significant risk for multiple metabolic disorders related to chronic disease. The paradigm of inactivity physiology argues that too much physical inactivity has deleterious effects on health independent of whether people meet the current exercise guidelines, and that physical inactivity is not the biological equivalent of too little exercise. His laboratory is currently using multidisciplinary approaches ranging from highly controlled laboratory studies where mechanisms related to novel biomarkers are studied to pragmatic studies involving how prolonged sitting impacts children in school and the workplace.

Marc Hamilton, Ph.D, Professor, Inactivity Physiology Laboratory is an internationally renowned expert in physical activity and his work has led to an entire new way that scientists, medical professionals, and corporations are thinking about preventing disease and making people feel well. His research has discovered that sitting too much is a powerful and direct cause of disease. Remarkably, this is distinct from how much time people spend exercising and a person’s nutrition. He is the scientist fathering this young and rapidly growing research field now composed of hundreds of other researchers around the world. Articles on Dr. Hamilton and this work are widely appearing in national newspapers like the Wall Street Journal, NY Times, USA Today, and in each of the major networks like ABC World News with Diane Sawyer and similar news programs throughout the world in other countries like Australia and England.


Hamilton M.T., and N. Owen. Sedentary Behavior and Inactivity Physiology. In: Physical Activity and Health, 2nd edition, C. Bouchard, S.N. Blair, and W. L. Haskell (Eds.). Human Kinetics, 2011.

Stephens BR, Granados K, Zderic TW, Hamilton MT, Braun B. Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake. Metabolism 60(7): 941-9, 2011. PMID:21067784.

Harrison, M., D.J. O’Gorman, N. McCaffrey, M.T. Hamilton, T.W. Zderic, B.P. Carson, N.M. Moyna Influence of acute exercise with and without carbohydrate replacement on postprandial lipid metabolism. Journal of Applied Physiology 106(3): 943-9. 2009. PMID:19112157.

Hamilton, M.T., G.N.Healy, T.W. Zderic, D. Dunstan, N. Owen. Too Little Exercise and Too Much Sitting: Inactivity Physiology and the Potential Need for New Recommendations on Sedentary Behavior. Current Cardiovascular Risk Reports, 2: 292-298, 2008.

Hamilton M.T., D.G. Hamilton, T.W. Zderic. The Role of Low Energy Expenditure and Sitting on Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease. Diabetes 56(11): 2655-2667, 2007. PMID:17827399.

Zderic TW, Hamilton MT. Physical Inactivity Amplifies the Sensitivity of Skeletal Muscle to the Lipid-Induced Downregulation of Lipoprotein Lipase Activity. J Appl Physiol. 100(1): 249-57, 2006. PMID:16195388.

Hamilton, M.T., D.G. Hamilton, T.W. Zderic. Exercise Physiology Versus Inactivity Physiology: An Essential Concept For Understanding Lipoprotein Lipase Regulation. ESSR. 32(4): 161-166, 2004. PMID:15604935.

Bey, L, N. Akunuri, P. E. Hoffman, P. Zhao, D.G. Hamilton, and M.T. Hamilton. Patterns In Global Gene Expression In Rat Skeletal Muscle During Unloading And Low-Intensity Ambulatory Activity. Physiological Genomics 13:157-167, 2003. PMID:12582208.

Bey, L. and M.T. Hamilton. A Molecular Reason to Maintain Daily Low-Intensity Activity: Suppression of Skeletal Muscle Lipoprotein Lipase Activity During Physical Inactivity. J. Physiol. (London) 551.2: 673-682, 2003. PMCID:PMC2343229.

Hamilton M.T, E Areiqat, D.G. Hamilton, and L. Bey. Plasma Triglyceride Metabolism In Humans And Rats During Aging And Physical Inactivity. International Journal of Sports Nutrition and Exercise Metabolism 11, 95-102, 2001. PMID:11915936.

Bey L, E. Areiqat, A. Sano, and M.T. Hamilton. Reduced lipoprotein lipase activity in postural skeletal muscle during aging. J. Appl. Physiol., 91: 687-692, 2001. PMID:11457782.

Booth, F.W., S.E. Gordon, C.J. Carlson, and M.T. Hamilton. Waging War on Modern Chronic Diseases: Primary Prevention through Exercise Biology. J. Appl. Physiol. 88(1):774-787, 2000. PMID:10658050.

Hamilton, M.T., J. Etienne, W.C. McClure, B.S. Pavey, and A.K. Holloway. Role of local contractile activity and muscle fiber type on LPL regulation during exercise. Am. J. Physiol. 275 (38): E1016-E1022, 1998. PMID:9843744. ^ top