Kirsten Stone, PhD
Nutrient Sensing and Adipocyte Signaling
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FRIEDRICH-SCHILLER UNIVERSITY JENA, GERMANY
Masters in Biology, July 1986
Ph.D. in Biology, April 1995
NATIONAL INSTITUTES OF HEALTH
Visiting Fellow at the National Institute of Diabetes, Digestive and Kidney Diseases, Laboratory of Cell Biology and Biochemistry
Advisor: Dr. J. Barsony
Mechanisms of physiological changes in insulin sensitivity, lipid metabolism, and energy expenditure resulting from a diet restricted in methionine
Mechanisms of cytokine transcytosis through the blood-brain barrier and functions of cytokines in endothelial cells of the blood-brain barrier
Cell biology of nuclear receptors, mechanisms of functional regulation such as nuclear import and export, protein-protein interactions, DNA-receptor interactions in cell-based systems using biochemical, methods of cell and molecular biology such as cloning, site-directed mutagenesis, amplification, PCR, quantitative PCR, electro mobility shift assays (EMSAs), Western blot analysis, protein expression, affinity purification, IP, cell culture, transfection, transactivation and proliferation assays, cell permeabilization assays, microscopical evaluation of living cells (incl. Confocal Laser Scanning Microscopy, FRAP and FRET)
Distribution of nuclear receptors in the central nervous system, functional studies using cell and tissue culture (incl. primary neuronal culture), immunohistochemistry, in situ hybridization, animal experiments (incl. behavioral; stereotactic brain injections)
Pharmacological studies of steroid actions on keratinocyte proliferation and differentiation, nongenomic actions of steroids (Ph.D. thesis)
Orgeron ML, Stone KP, Wanders D, Cortez CC, van NT, Gettys TW. The impact of dietary methionine restriction on biomarkers of metabolic health. Prog Mol Biol Transl Sci. 121 (2014) 351-76
Ghosh S, Wanders D, Stone KP, Van NT, Cortez CC, Gettys TW. A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats. FASEB J. 2014 in press
Desiree Wanders, Sujoy Ghosh, Kirsten P. Stone, Nancy T. Van, and Thomas W. Gettys.Anti-inflammatory responses to models of dietary restriction: Relevance to biomarkers of metabolic disease. Biofactors (2013) in press. 40 (2014) 13-26
Barbara Hasek, Anik Boudreau, Jeho Shin, Daorong Feng, Matt Hulver, Nancy Van, Amanda Laque, Laura K. Stewart, Kirsten P. Stone, Desiree Wanders, Sujoy Ghosh, Jeffrey Pessin, and Thomas W. Gettys. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes (2013) in press. 62 (2013) 3362-3372
Wu X, Hsuchou H, Kastin AJ, He Y, Khan RS, Stone KP, Cash MS, Pan W. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Ralpha receptor.
Psychoneuroendocrinology 36 (2011) 266-78.
Kirsten P. Stone, Abba J. Kastin, Hung Hsuchou, Chuanhui Yu, Weihong Pan. Rapid endocytosis of interleukin-15 by cerebral endothelia. Journal of Neurochemistry 116 (2011) 544-553.
Kirsten P. Stone, Abba J. Kastin, Weihong Pan. NF?B is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia. Cell Physiology & Biochemistry 28 (2011) 115-124.
Hung Hsuchou, Abba J. Kastin, Hong Tu, Emily N. Markadakis, Kirsten P. Stone, Yuping Wang, Steven B. Heymsfield, Streamson S. Chua, Jr., Silvana Obici, I. Jack Magrisso, Weihong Pan. Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. Peptides 32 (2011) 1392-9.
Reas S. Khan, Chuanhui Yu, Abba J. Kastin, Yi He, Rudolph H. Ehrensing, Hung Hsuchou, Kirsten Prüfer Stone and Weihong Pan. Brain activation by peptide Pro-Leu-Gly-NH2 (MIF-1). International Journal of Peptides (2010), 2010. pii: 537639.
Xiaojun Wu, Weihong Pan, Kirsten P. Stone, Yan Zhang, Hung Hsuchou, Abba J. Kastin. Expression and signaling of novel IL15R splicing variants in cerebral endothelial cells of the blood-brain barrier. Journal of Neurochemistry 114 (2010), 122-9.