Theodore Zderic, Ph.D.

Third Party Affiliate

Inactivity Physiology
(225) 763-2698
(225) 225-7630
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University of Washington, B.S. 1994, Cell and Molecular Biology
University of Montana, M.S. 1997, Exercise Physiology
University of Texas-Austin, Ph.D. 2002, Exercise Physiology
University of Missouri, Fellow 2009, Biomedical Sciences


Dr. Zderic has been focused on understanding how prolonged sedentary behavior (“too much sitting”) impacts human health. Trained in both animal and human experimental designs, he has been an integral member of a team performing translational studies using diverse tools from molecular biology and physiology, and the classification of human behavior with accelerometry and inclinometry. For example, he has recently reported that prolonged sitting in less than a day’s time can downregulate the expression of LPP1, an enzyme linked to coagulation and cancer. Interestingly, exercise training could not counter the suppressive effects of prolonged sitting. These findings highlight the central tenet of inactivity physiology that exercise and physical inactivity can operate via independent molecular pathways and thus traditional moderate–vigorous exercise is not always an effective antidote to prolonged sitting. In addition, from a behavioral perspective, he has learned through analyses of inclinometry and accelerometry data that the amount of habitual exercise one performs is unrelated to their amount of time spent sitting, indicating that meeting the traditional physical activity guidelines for aerobic exercise is unlikely to impact sedentary or sitting behaviors. These types of studies reflect his overall goal of identifying robust metabolic pathways affected by prolonged sitting and the development of effective countermeasures. The hope is this will lead to scientific breakthroughs that will have a wide reaching effect on human health.


Newton RL Jr, Han H, Zderic T, Hamilton M. The energy expenditure of sedentary behavior: a whole room calorimeter study. PLoS One 8(5):e63171, 2013.

Granados K, Stephens BR, Malin SK, Zderic TW, Hamilton MT, Braun B. Appetite regulation in response to sitting and energy imbalance. Appl Physiol Nutr Metab 37(2):323-33, 2012.

Craft LL, Zderic TW, Gapstur SM, Vaniterson EH, Thomas DM, Siddique J, Hamilton MT. Evidence that women meeting physical activity guidelines do not sit less: an observational inclinometry study. Int J Behav Nutr Phys Act. Oct 4;9:122, 2012.

Zderic TW, Hamilton MT. Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting). Lipids Health Dis. Oct 12;11:137, 2012.

Ivy JL, Zderic TW, Fogt D. Prevention and treatment of NIDDM with exercise training. Exerc Sport Sci Rev 27(1): 1-35, 1999.

Harrison M, Moyna NM, Zderic TW, O'Gorman DJ, McCaffrey N, Carson BP, Hamilton MT. Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise. Lipids Health Dis. 11(1):64, 2012.

Stephens BR, Granados K, Zderic TW, Hamilton MT, Braun B. Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake. Metabolism 60(7): 941-9, 2011.

Hamilton MT, Healy GN, Zderic TW, Dunstan D, Owen N. Too little exercise and too much sitting: inactivity physiology and the potential need for new recommendations on sedentary behavior. Current Cardiovascular Risk Reports, 2: 292-298, 2008.
Hamilton MT, Hamilton DG, Zderic TW. The role of low energy expenditure and sitting on obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 56(11): 2655-2667, 2007.

Zderic TW, Hamilton MT. Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activity. J Appl Physiol. 100(1): 249-57, 2006.

Hamilton MT, Hamilton DG, Zderic TW. Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation. Exerc Sport Sci Rev 32(4): 161-166, 2004.

Zderic TW, Davidson CJ, Schenk S, Byerley LO, Coyle EF. High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise. Am J Physiol Endocrinol Metab 286(2): E217-25, 2004.

Zderic TW, Schenk S, Davidson CJ, Byerley LO, Coyle EF. Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by {beta}-adrenergic blockade. Am J Physiol Endocrinol Metab 287(6): E1195-201, 2004.

Schenk S, Davidson CJ, Zderic TW, Byerley LO, Coyle EF. Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue. Am J Clin Nutr 78(4): 742-748, 2003.

Zderic TW, Coggan AR, Ruby BC. Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases. J Appl Physiol 90(2): 447-453, 2001. ^ top