Diana Obanda, Ph.D.
Diabetes and Nutrition
BS. Moi University, Kenya
PhD. Louisiana State University
1.Obesity induced insulin resistance. The role of lipid metabolites i.e triglycerides, diglycerides and sphingolipids in the pathogenesis of insulin resistance in skeletal muscle, adipose tissue and liver. Sphingolipids are important in cell structure and cell signaling. I focus on how insulin resistance results from disruption of pathways of their synthesis and metabolism.
2.Botanical compounds that are insulin sensitizers. Underlying cellular mechanisms by which the bioactives of certain plants improve insulin sensitivity in skeletal muscle cells that exhibit inflammation and insulin resistance.
Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ and Cefalu W. Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells. Diabetes. 2012. 61(3):597-605. PMCID: PMC3282822
Obanda DN and Cefalu W. 2013. Modulation of Cellular Insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells. J. Nutr. Biochem. 2013. 24 (8):1529–1537. PMID: 23481236.
Bajpeyi S, Myrland CK, Covington JD, Obanda DN, Cefalu WT, Smith RS, Rustan AC and Ravussin E. 2013. Lipid in skeletal muscle myotubes is associated to the donors’ insulin sensitivity and physical activity phenotypes. Obesity. Published online 1 July 2013. doi:10.1002/oby.20556.
Obanda DN, Ribnicky D, Raskin I and Cefalu WT. Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells. Nutrition. 2014. In Press. doi: 10.1016/j.nut.2014.03.006. http://authors.elsevier.com/sd/article/S0899900714001403
Obanda DN, Yu Y, Wang ZQ, and Cefalu WT. Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle. J. Nutr. Biochem. 2015. In press.