Diana Obanda, Ph.D.
Diabetes and Nutrition
BS. Moi University, Kenya
PhD. Louisiana State University
1. Lipids or free fatty acids in cells are converted into lipid metabolites i.e triglycerides, diglycerides and sphingolipids that are behind the pathogenesis of insulin resistance at cellular level in skeletal muscle, adipose tissue and liver. Sphingolipids are important in cell structure and cell signaling. The major focus of this research is sphingolipids and their role on insulin sensitivity in skeletal muscle and adipose tissue. I focus on how insulin resistance results from disruption of pathways of their synthesis or accumulation.
2. Botanical compounds that are insulin sensitizers. Underlying cellular mechanisms by which the bioactives of certain plants improve insulin sensitivity in skeletal muscle cells that exhibit inflammation and insulin resistance.
Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ and Cefalu W. 2012. Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells. Diabetes. 61(3):597-605. PMCID:PMC3282822
Obanda DN and Cefalu W. 2013. Modulation of Cellular Insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells. J. Nutr. Biochem. 2013 Mar 4. pii: S0955-2863(13)00010-7. doi: 10.1016/j.jnutbio.2012.12.014.