EDUCATION2009 - Postdoctoral Training (Islet Biology), Duke University Medical Center, Durham, NC
2004 - Ph.D. (Biochemistry), Louisiana State University Health Sciences Center, New Orleans, LA
1999 - B.S. (Biochemistry), Louisiana State University, Baton Rouge, LA
RESEARCH INTERESTSMy laboratory focuses on understanding the inflammatory processes relevant to the eventual onset of T1DM and T2DM, with emphasis on pancreatic beta-cells. Our work on elucidating the transcriptional mechanism(s) of interleukin-1 responsive genes has evolved into projects that 1) investigate how islet beta-cells influence leukocytic recruitment and activity within the exocrine and endocrine pancreas; and 2) seek to understand intracellular signaling pathways regulating inflammatory responses. Our approaches are truly interdisciplinary, involving bioanalytical mass spectrometry, proliferation and transcriptional assays, fluorescence microscopy, immunological and enzymatic assays, and transgenic mouse models.
SELECTED PUBLICATIONS2017 Susan J. Burke, Heidi M. Batdorf, Adrianna E. Eder, Michael D. Karlstad, David H. Burk, Robert C. Noland, Z. Elizabeth Floyd and J. Jason Collier*. Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Non-obese Diabetic Mice. American Journal of Pathology. Mar;187(3):614-626. doi: 10.1016/j.ajpath.2016.11.009.
2016 Susan J. Burke, Michael D. Karlstad, Adrianna E. Eder, Kellie M. Regal, Danhong Lu, David H. Burk, and J. Jason Collier*.
Pancreatic ß-Cell production of CXCR3 ligands precedes diabetes onset. Biofactors. Nov 12;42(6):703-715. doi: 10.1002/biof.1304.
2016 Susan J. Burke, Michael D. Karlstad, and J. Jason Collier*. Pancreatic Islet Responses to Metabolic Trauma. Shock. Sep;46(3):230-8. doi: 10.1097/SHK.0000000000000607. FEATURED ON THE JOURNAL COVER.
2016 Thomas Laeger, Diana C. Albarado, Susan J. Burke, Lexus Trosclair, John Hedgepeth, Hans-Rudolf Berthoud, Thomas W. Gettys, J. Jason Collier, Heike Münzberg, and Christopher D. Morrison. Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2. Cell Reports, Jul 19;16(3): 707-16
2015 Susan J. Burke, Krisztian Stadler, Danhong Lu, Evanna Gleason, Anna Han, Dallas R. Donohoe, Richard C.Rogers, Gerlinda E. Hermann, Michael D. Karlstad, and J. Jason Collier*. IL-1 Reciprocally Regulates Chemokine and Insulin Secretion in Pancreatic beta-cells via NF-kB. American Journal of Physiology-Endocrinology and Metabolism. Oct. 15; 309 (8): E715-26. doi: 10.1152/ajpendo.00153.2015.
2015 Susan J. Burke and J. Jason Collier*. Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation? INVITED MINIREVIEW. SPECIAL ISSUE: TRANSCRIPTIONAL REGULATION OF PRO-INFLAMMATORY GENES. Biomolecules 5; 1020-1034. doi:10.3390/biom5021020.
2015 Susan J. Burke, Michael D. Karlstad, Kellie M. Regal, Tim E. Sparer, Danhong Lu, Carrie M. Elks, Ryan W. Grant, Jacqueline M. Stephens, David H. Burk and J. Jason Collier*. CCL20 is elevated during obesity and differentially regulated by NF-kB subunits in pancreatic beta-cells.
Biochimica et Biophysica Acta – Gene Regulatory Mechanisms Apr 13; 1849(6):637-652. doi:10.1016/j.bbagrm.2015.03.007.
2015 Susan J. Burke, Amanda L. May, Robert C. Noland, Danhong Lu, Marcela Brissova, Alvin C. Powers, Elizabeth M. Sherrill, Michael D. Karlstad, Shawn R. Campagna, Jacqueline M. Stephens, and J. Jason Collier*. Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet beta-cell Function. Journal of Biological Chemistry May 22; 290(21):13401-13416. doi: 10.1074/jbc.M114.632190.