William Hansel, Ph.D.
William Hansel Cancer Prevention
Ph.D., Cornell University, New York, NY, 1947, Animal Physiology
M.S., Cornell University, New York, NY, 1949, Animal Physiology
Dr. Hansel's major research interests are in cancer, reproductive biology and nutrition. He currently leads a group of scientists at the Pennington Center and on the LSU Campus that is developing a new method for treating prostate, breast, testes, and ovarian cancers based on targeting lytic peptides to gonadotropin receptors on the cancer cell membranes.
1. Leuschner, C. and Hansel, W. Targeting breast and prostate cancers through their hormone receptors. Biol. Reprod. 73:860-865, 2005
2. Hansel, W. Targeting breast, prostate, ovarian and testicular cancers through their hormone receptors. Biol. Reprod. 73: 850, 2005 (Special Paper)
3. Leuschner, C., Kumar, CSSR, Hansel, W, and Hormes, J. Targeting breast cancer cells and their metastases through luteinizing hormone releasing hormone (LHRH) using magnetic nanoparticles. J. Biomed. Nanotechnol. 2:229-233, 2005.
4. Leuschner, C, Kumar, C, Hansel, W, Zhou, J, Soboyejo, W, and Hormes, J. LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases. Breast Cancer Res. Treat. 99:163-76, 2006.
5. Hansel, W, Leuschner, C, and Enright, F. Destruction of breast cancers and their
metastases by lytic peptides in vitro and in vivo. Molecular and Cellular Endocrinology 260-262:183-189, 2007.
6. Hansel, W, Leuschner, C, and Enright, F. Conjugates of lytic peptides and LHRH or ?CG target and cause necrosis of prostate cancers and metastases. Molecular and Cellular Endocrinology 269:26-33, 2007.
7. Jia, L, Noker, PE, Piazza, GA, Leuschner, C, Hansel, W, Gorman, GS, Coward, LU and Tomaszewski, J. Pharmacokinetics and pharmacodynamics of Phor21-?CG(ala), a lytic peptide conjugate. J. of Pharmacy and Pharmacology 60:1-8, 2008.
8. Bogacki, M, Enright, F, Todd, WJ, and Hansel, W. Immune response to lytic peptides conjugated to a ?CG fragment in treated BALB/C mice. Reprod. Biol. 8:135-147, 2008.
9. Hansel, W. The essentiality of the epididymal fat pad for spermatogenesis. Endocrinology 151:5565-5567, 2010.
10. Aggarwal, S, Ndinguri, M.W., Solipuram, R., Wakamatsu, N, Hammer, RP, Ingram, D, and Hansel, W. [DLys6] LHRH-Curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. International Journal of Cancer 129:1611-1623, 2011.
11. Callery, EC, Hansel, W, and Bartlewski, P.W. The effects of a low dose of ßCG fragment-lytic peptide conjugate on ovarian function and gonadotropin secretion in ewes: A randomized controlled trial. Reprod. Biol. 10:195-213, 2010.
12. Hansel, W. From Hyperkeratosis to Apoptosis: Lessons learned from 65 years of research. Biol. Reprod. 87: 1-11, 2012.
13. Hansel, W. After 65 years, research is still fun. Annual Review of Animal Biosciences 1: 1-20, 2013.
14. Mcleod, BD, Hansel, W, Bartlewski, PM and Buenviaje. Pituitary and ovarian responses after an application of a low dose of the LHRH-lytic peptide conjugate during the pre-ovulatory period in ewes. Reprod. Biol. (In Press), 2012.
1. Aggarwal, S., Hansel, W., Gimble, J., Chakravanti, N. Adipogenic risk factors in breast cancer. In: Obesity and Cancer Research. NovoScience Publications, Inc., NY, NY, 2008.
2. Aggarwal, S., Hansel, W., and Solipuram, R. IL-24 in regulation of anti-tumor immune response and in signaling. In: Targeted Cancer Immune Therapy. Eds. J. Lustgarten, et al. Springer Science and Business Media, LLC, 2009.