Roy Martin, Ph.D.

Adjunct Professor

Department/Laboratory:
Antioxidant and Gene Regulation Lab
Phone:
(225) 270-1859
 
Fax:
(225) -
Send E-mail 
 

EDUCATION

Ph.D., University of California, Davis, CA, 1970, Nutrition
M.S., University of Florida, Gainesville, FL, 1965, Dairy Science
B.S., University of Louisiana Lafayette, LA, 1964, Animal Nutrition

RESEARCH INTERESTS

The focus of Dr. Martin's research has been on nutrient sensing mechanisms in the gut and brain and how these mechanisms may be altered by dietary fermentable carbohydrates, gut microbiota and fermentation end products. It has been shown that dietary fermentable carbohydrates decrease plasma cholesterol and triglycerides, improve insulin sensitivity, decrease obesity, and produce anticancer effects in humans.

SELECTED PUBLICATIONS

Tachon S, Zhou J, Keenan M, Martin R, Marco M.. 2012. The intestinal microbiota in aged mice is modulated by dietary resistant starch and correlated to improvementsin host responses FEMS Microbiology Ecology. Accepted date: 09-Aug-2012.

Purpera MN, Shen L, Taghavi M, Münzberg H, Martin RJ, Hutson SM, Morrison CD. 2012. Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus. J Endocrinol. 212(1):85-94.

Keenan MJ, Martin RJ, Raggio AM, McCutcheon KL, Brown IL, Birkitt A, Newman SS, Skaf, J, Hegsted M, Tulley RT, Blair E, Zhou J. 2012. A microarray study indicates high-amylose resistant starch increases hormones and improves structure and function of the GI tract. Journal of Nutrigenetics and Nutrigenomics 5(1):26-44.

Zhou J, Keenan MJ, Keller J, Fernandez-Kim SO, Pistell PJ, Tulley RT, Raggio AM, Shen L, Zhang H, Martin RJ, Blackman MR. 2011. Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. Mol Nutr Food Res. 2012 Mar;56(3):515-8.

Keenan MJ, Zhou J, Raggio AM, McCutcheon KL, Senevirathne R, Goldsmith F, Janes M, Tulley RT, Shen L, Vidrine K, Williams C, Charrier JA, Martin RJ 2102. Mechanism by which resistant starch produces gut hormones and reduces body fat. In: Dietary Fiber and Health. SPi Global, Editors, Cho S and Almeida N.

Shen L, Keenan MJ, Raggio A, Williams, C, Martin RJ. 2011. Dietary resistant starch improves maternal glycemic control in Goto-Kakizaki rat. Mol Nutr Food Res. 55(10):1499-508.

Zhou J, Keenan MJ, Losso J, Raggio AM, Shen L, McCutcheon KL, Tulley RT, Blackman MR, Martin RJ. 2011. Dietary whey protein decreases food intake and body fat in rats. Obesity 19:1568-1573.

Zheng J, Enright F, Keenan M, Finley J, Zhou J, Ye J, Greenway F, Senevirathne RN, Gissendanner CR, Manaois R, Prudente A, King JM, Martin R. 2011. Resistant starch, fermented resistant starch and short chain fatty acids reduced intestinal fat deposition in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry 58:4744-4748.

Keenan MJ, Zhou J, Senevirathne RN, Janes M, Martin RJ. 2010. Lower gut hormones and health effects associated with consumption of fermentable fibers. In: Nondigestible Carbohydrates and Digestive Health. IFT Press/Wiley-Blackwell, Ames, IA. Editors, Paeschke TM, Aimutis WR (December 2010; ISBN: 978-0-8138-1762-0).

Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan MJ, Gao Z, Ye J. 2010. Uncoupling of inflammation and insulin resistance by NF-?B in transgenic mice through elevated energy expenditure. Journal of Biological Chemistry 285:4637-4644.

Zheng J, Enright F, Keenan M, Finley J, Zhou J, Ye J, Greenway F, Senevirathne RN, Gissendanner CR, Manaois R, Prudente A, King JM, Martin R. 2010. Resistant starch, fermented resistant starch and short chain fatty acids reduced intestinal fat deposition in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry 58:4744-4748.

Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. 2009. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58(7):1509-17.

Zhou J, Martin RJ, Tulley RT, Raggio AM, Shen L, Lissy E, McCutcheon K, Keenan MJ. 2009. Failure to ferment dietary resistant starch in specific mouse models of obesity results in no body fat loss. J Agric Food Chem. 57(19):8844-51.

Tulley RT, Appel MJ, Enos TG, Hegsted M, McCutcheon KL, Zhou J, Raggio AM, Jeffcoat R, Birkett A, Martin RJ, Keenan MJ. 2009. Comparative methodologies for measuring metabolizable energy of various types of resistant high amylose corn starch. J Agric Food Chem. 23;57(18):8474-9.

Shen L, Keenan MJ, Martin RJ, Tulley RT, Raggio AM, McCutcheon KL, Zhou J. 2009. Dietary Resistant Starch Increases Hypothalamic POMC Expression in Rats. Obesity (Silver Spring). 17(1): 40–45.

Zhou J, Martin RJ, Tulley RT, Raggio AM, McCutcheon KL, Shen L, Danna SC, Tripathy S, Hegsted M, Keenan MJ. Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab. 2008;Nov;295(5):E1160-6.

Morrison CD, Xi X, White CL, Ye J, Martin RJ. 2007. Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Am J Physiol Endocrinol Metab.293(1):E165-71. ^ top