John S McIlhenny Skeletal Muscle Physiology Laboratory
- Robert Noland, PhD
The goal of this laboratory is to understand and characterize the molecular mechanism(s) of mitochondrial dysfunction in skeletal muscle and its relationship to obesity, insulin resistance, type 2 diabetes mellitus, and aging.
ABOUT THIS LAB
The Skeletal Muscle Metabolism laboratory is focused on the measurement of skeletal muscle metabolism and seeks to understand and characterize the role of metabolic proteins and mitochondrial dysfunction in metabolic diseases including obesity, diabetes, insulin resistance and some muscle defects that occur with aging (sarcopenia and oxidative stress). Central to this investigation is the rhomboid mitochondrial protease named PARL and the adiponectin/AdipoR axis.