Islet Biology and Inflammation Laboratory

FACULTY

  • Jason Collier, Ph.D.

RESEARCH FOCUS

The goal of this laboratory is to understand the basic mechanisms regulating inflammation, proliferation, and insulin secretion in pancreatic beta-cells. Delineating the signaling pathways that reduce proliferation and impair insulin secretion are relevant to the eventual onset of T1DM and T2DM.

ABOUT THIS LAB

Our recent work elucidating the transcriptional mechanism(s) of interleukin-1 responsive genes has evolved into projects that 1) investigate how islet beta-cells influence leukocytic recruitment and activity within the exocrine and endocrine pancreas; and 2) seek to understand intracellular signaling pathways regulating inflammatory responses. Our approaches are truly interdisciplinary, involving bioanalytical mass spectrometry, transcriptional assays, fluorescence microscopy, immunological and enzymatic assays, and transgenic mouse models.