Our Faculty
Indu Kheterpal, 
Assistant Professor

Department/Laboratory:
Protein Structural Biology
Proteomics and Metabolomics Core
Phone:
(225) 763-2534
 		 Fax:
(225) 763-2525
Send E-mail 
 
Education:
Ph. D., University of California at Berkeley, 1998, Biophysical Chemistry
B.S., Pennsylvania State University, 1993, Chemistry

Website:
http://labs.pbrc.edu/proteomics
Research Interests:

Mass spectrometric and biochemical investigations of structure of proteins and protein complexes, especially amyloid fibrils associated with Alzheimer’s disease and Diabetes; Isolation and characterization of protein complexes; Proteomic analysis of cells, tissue and biological fluids.
Selected Publications:

Kheterpal, I.; Wetzel, R. Hydrogen/deuterium exchange mass spectrometry – a window into the amyloid structure, Acct. Chem. Res., 2006, 39, 584-593.

Kheterpal, I.; Chen, M.; Cook, K.D.; Wetzel, R. Structural differences in Aß amyloid protofibrils and fibrils mapped by hydrogen exchange-mass spectrometry with on-line proteolytic fragmentation. J. Mol. Biol. 2006, 361, 785-795.

Kheterpal, I.; Cook, K.D.; Wetzel, R. Hydrogen deuterium exchange mass spectrometry analysis of protein aggregates. Methods in Enzymology 2006, 413, 140-166.

O’Nuallain, B.; Shivaprasad, S.; Kheterpal, I.; Wetzel, R. Thermodynamics of Aß(1-40) amyloid fibril elongation. Biochemistry 2005, 44, 12709-12718.

Williams, A.D.; Sega, M.; Chen, M.; Kheterpal, I.; Geva, M.; Berthelier, V.; Kaleta, D.T.; Cook, K.D.; Wetzel, R. Structural properties of Aß protofibrils stabilized by a small molecule. Proc. Natl. Acad. Sci. USA 2005, 102, 7115-7120.

Whittemore, N.A.; Mishra, R.; Kheterpal, I.; Williams, A. D.; Wetzel, R.; Serpersu, E.H. Hydrogen-Deuterium (H/D) Exchange Mapping of Aß (1-40) Amyloid Fibril Secondary Structure Using Nuclear Magnetic Resonance Spectroscopy, Biochemistry, 2005, 44, 4434-4441.

Williams, A.; Portelius, E.; Kheterpal, I.; Guo, J-t.; Cook, K. D.; Xu, Y.; Wetzel, R. Mapping Aß Amyloid Fibril Secondary Structure by Scanning Proline Mutagenesis, J. Mol. Biol. 2004, 335, 833-842.

Kheterpal, I.; Lashuel, H. A.; Hartley, D. M.; Walz, T.; Lansbury, P. T. Jr.; Wetzel, R. Aß protofibrils Possess a Stable Core Structure Resistant to Hydrogen Exchange, Biochemistry 2003, 42, 14092-14098.

Kheterpal, I.; Wetzel, R.; Cook, K. D. Enhanced Correction Methods for Hydrogen Exchange-Mass Spectrometric Studies of Amyloid Fibrils, Protein Science 2003, 12, 635-643.

Kheterpal, I.; Williams, A.; Murphy, C.; Bledsoe, B.; Wetzel, R. Structural Features of the Aß Amyloid Fibril Elucidated by Limited Proteolysis, Biochemistry 2001, 40, 11757-11767.

Kheterpal, I.; Zhou, S.; Cook, K. D.; Wetzel, R. Aß Amyloid Fibrils Possess a Core Structure Highly Resistant to Hydrogen Exchange, Proc. Natl. Acad. Sci. USA 2000, 97, 13597-13601.

Scherer, J. R.; Kheterpal, I.; Radhakrishnan, A.; Ja, W. W.; Mathies, R. A. Ultra-High Throughput Rotary Capillary Array Electrophoresis Scanner for DNA Sequencing and Analysis, Electrophoresis 1999, 20, 1508-1517.

Kheterpal, I; Mathies, R. A. Capillary Array Electrophoresis DNA Sequencing, Analytical Chemistry 1999, 71, 31A-37A.

Kheterpal, I.; Li, L.; Speed, T. P.; Mathies, R. A. A Three-Wavelength Labeling Approach for DNA Sequencing Using Energy Transfer Primers and Capillary Electrophoresis, Electrophoresis 1998, 19, 1403-1414.

Kheterpal, I.; Scherer, J. R.; Clark, S. M.; Radhakrishnan, A.; Ju, J.; Ginther, C. L.; Sensabaugh, G. F.; Mathies, R. A. DNA Sequencing Using A Four-Color Confocal Fluorescence Capillary Array Scanner, Electrophoresis 1996, 17, 1852-1859.

Ju, J.; Kheterpal, I., Scherer, J.R.; Ruan, C.; Fuller, C. W.; Glazer, A. N.; Mathies, R. A. Design and Synthesis of Fluorescence Energy Transfer Dye-Labeled Primers and their Application for DNA Sequencing and Analysis, Analytical Biochemistry 1995, 231, 131-140.

Hayes, M. A.; Kheterpal, I.; Ewing, A. G. Electroosmotic Flow Control and Surface Conductance in Capillary Zone Electrophoresis, Analytical Chemistry 1993, 65, 2010-2013.

Hayes, M. A.; Kheterpal, I.; Ewing, A. G. Effects of Buffer pH on Electroosmotic Flow Control by an Applied Radial Voltage for Capillary Zone Electrophoresis, Analytical Chemistry 1993, 65, 27-31.


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